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AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and .The American College of Sports Medicine acknowledges that AAS, in the presence of adequate diet, can contribute to increases in body weight, often as lean mass increases and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals.

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are steroidal androgens that include natural androgens like testosterone as well as synthetic substances that are structurally related and have similar effects to testosterone.

They are anabolic and increase protein within cells, especially in skeletal muscles.

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